You are going to have to define anime first...
Such things as Fireball XL5, Stingray, Supercar, Scooby-Do, Tom & Jerry (the pre PC ones), Magic Roundabout, Bill & Ben... are what got me hooked.
But I've never liked Mickey Mouse: in fact I detest it. TBF I'm not a fan of American animation (apart from Hanna-Barbara and some Looney Tunes).
I'm relatively new to Japanese animation (not counting Poke-0-mon) but I've not found one I don't like yet (well, some of the hard-core sexually explicit ones make me cringe but there is still artistic merrit in them).
The anime that really got me interested in Japanese anime is Girl's High but it's been like heroine since...
(Apologies for spelling errors, too busey to check references).