Health Japanese study finds coffee compound slows growth of colorectal cancer cells

[thomas]

Coffee just got healthier:

A research team in Japan has identified how caffeic acid, a polyphenol found in coffee, can suppress the growth of colorectal cancer cells. The findings point to a possible role in treatment and prevention, though the work is still in its early stages. Earlier epidemiological studies had suggested that people who drink coffee may face a lower risk of developing colorectal cancer. What was not clear was which components of coffee were responsible, or how they act in the body.

The researchers, including Motoki Watanabe of Kyoto Prefectural University of Medicine and Shogen Boku of Kansai Medical University Hospital, examined polyphenols, such as chlorogenic acid, which is abundant in coffee. In the intestine, these compounds are broken down and converted into caffeic acid. The team then examined how this substance affects colorectal cancer cells at the molecular level. First, they confirmed that adding caffeic acid to colorectal cancer cells significantly suppressed the formation of "colonies" of cancer cells. They additionally found that caffeic acid binds to a protein called "RPS5," which is known to be associated with a poor outlook for recovery in colorectal cancer patients. Furthermore, they found that suppressing the expression of RPS5 -- the process by which gene information is turned into a function -- caused the cell cycle of cancer cells to halt at the preparatory stage before DNA replication.

Japan research uncovers how coffee constituent limits growth of colorectal cancer cells - The Mainichi

KYOTO -- A team of researchers in Japan has uncovered the mechanism by which caffeic acid, a polyphenol found in coffee, suppresses the growth of colo

mainichi.jp

Caffeic acid suppresses cyclin D1 expression by directly binding to ribosomal protein S5 in colorectal cancer cells - Scientific Reports

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, and dietary components such as coffee have been epidemiologically associated with a reduced risk of CRC. However, the molecular mechanisms underlying this effect remain elusive. In this study, we found that caffeic...

www.nature.com

 

[Ukigumo]

I assume (hope) you still drink the coffee for the beneficial effects?