The only thing I miss is the background chatter/info I would get in the office to get a better feel of what is going on in terms of office politics, other projects, etc.
Other than that no issues. Since I'm often on the phone with Japan in the evenings, being able to roll out of bed and go to "work" or not having to rush home in time for dinner before my conf calls has been a huge plus. I get the occasional Internet connection hiccup but generally it's been pretty stable.