I haven't been able to suss out the main message on the scroll, so I'll leave that to someone else.
Based on the signature on the left, the artist appears to be Seki Bokuou (関牧翁), a Buddhist monk who lived in the previous century. He was associated with the Tenryuuji (天龍寺) temple in Kyoto, serving at one time as chief abbot. The calligraphy on the left appears to read Bokuou (in kanji: 牧翁)
The stamps in the lower left appear to read 「天龍沙門」 (Tenryuu "shramana") and 「牧翁」.
The resolution of your photo is not sufficient to read the stamp in the upper right, but based on similar works from Seki Boukou, it probably reads 「臨済正宗」which refers to the Rinzai school of Zen Buddhism, to which the temple Tenryuuji belongs.
If you search the Internet using the kanji version of Seki Bokuou's name, you can find other images of his works, and the signature seems to match well with yours. One such example is here:
【五】天龍寺派管長 関牧翁 『無事』 紙本 肉筆 ... - ヤフオク!
Information on the artist in Japanese, partly translated to English, can be found here:
江戸時代の絵画、書、和歌、俳句、古文書 - 南竹の収蔵品f
More information is here, but only in Japanese:
作家検索サンプル 関 牧翁
There is also a Japanese-language Wikipedia page for him, but with only limited information:
関牧翁 - Wikipedia