Users receiving the kits swab their oral cavity for cell samples to be returned to the company in a return envelope. About three weeks later, they can check the results online. The kits cost 6,050 JPY (roughly USD 43), tax included, and can be purchased through Amazon Japan. Alcohol is successively broken down into the toxic substance acetaldehyde, then the even more benign acetic acid, by the action of enzymes in the kidneys. If the enzymes cannot keep pace, acetaldehyde builds up, resulting in hangover symptoms such as headache and nausea. One's ability to break down alcohol depends on the genes of these enzymes, meaning there are variations in the way people respond to alcohol and how it affects their health.