Can't choose one.. here's a few good ones.. I have a bunch saved on my computer heh.. Family Guy is King...
Lois: You should spend some time with our kids, Peter. And with me.
Peter: Uh, what could me and you do together?
[Lois giggles]
Peter: Lois. You've got a sick mind.
Lois: Peter, I'm talking about making love.
Peter: Oh. I thought you wanted us to murder the children and harvest their organs for beer money.
Meg Griffin: You could kill all the girls who are prettier than me.
Death: Well that would just leave England.
Li: Stewie, come complete our rainbow.
Stewie Griffin: I've got a better idea. Let's go play "swallow the stuff under the sink."
[At a job interview]
Interviewer: So where do you see yourself in five years?
Peter : [Thinking to himself "Don't say doing you wife. Don't say doing your wife."] Doing your... son ?
Peter: Oh, okay, here's another riddle. A woman has two children. Now, a homicidal maniac tells her she can only keep one. Which one does she let 'im kill?
Brian: That's, that's not a riddle. That's, that's just terrible.
Peter: Wrong!... the ugly one.
*Police Officer Pulls Peter over in car*
Police Officer: License and reg... hey, aren't you the guy who found out he's part black?
Peter Griffin: Yes I am.
Police Officer: Report of a possible stolen vehicle.
Peter Griffin: But this is my car.
Police Officer: Suspect becoming unruly
Peter Griffin: Wha...
Police Officer: Officer down.
*Officer falls to ground, police cars surround Peter*
Peter Griffin: Make like Siamese twins and split... and then one of you die.
Protestors: Free Tibet! Free Tibet!
Peter Griffin: I'll take it!
[He runs to a nearby phone booth]
Peter Griffin: Hello, China? I have something you may want. But it's gonna cost ya. That's right. All the tea.
Lois Griffin: Peter, where the hell have you been? We had a date.
Peter Griffin: Oh sorry, honey, I must have lost track of the time. But what do you say, eh? 'Think the guys will like it?
Lois Griffin: This is why you missed our dinner? To make a bar for your friends?
Peter Griffin: Yeah, isn't it great? Oh boy, I feel just like Tim Allen. I build stuff and I have a criminal record.
[Grunts]
Ahahaha.. Man I love Family Guy..