Here's a couple of examples.
(Watashi ha) donna ni mazui ryouri demo, tsuma ga tsukutta mono de areba kesshite monku ha iimasen.
No matter how terrible the dish, if it was cooked by my wife, I would never complain.
Kanojo ga donna doryokuka demo, itsuka orinpikku ni derareru to ha gagirimasen.
It doesn't matter how much of a hard worker she is, there is no guarantee that she will one day be able to compete in the olympics.
Kodomo wo sodateru no ha totemo taihen na shigotodesu. Donna hito demo ii oya ninareru wake deha arimasen.
Raising a child is a hard work. Not everyone can become a good parent.