Main wholesalers can be found in and around Ningyocho and Asakusabashi...major houses who limit their clients to commercial clients require you to become registered and to open a commecial account. This takes time and there is no gurantee (even in this recession) that you will be accepted as a client.
Alt. Outlet shops are spinging up everywhere in the world offering "seconds" and big discounts.
There was an outlet in Shimokitazawa that sold female(urban/office fashion wear) retail at wholesale prices. Just start walking around the areas.