One aspect of "take to the road" is an element of a quest or journey. The traveler is going in order to find/discover something--about the world, people, themselves, or maybe all three.
The myth of the quest is ancient back to the greeks and far beyond. It may be why early humans (and pre-humans) peopled the world, getting to australia some 40,000+ years ago, and as far as the tip of south america (monte verde) maybe 18,500 years ago.
When you take to the road, to be a true journey it will become a path to self discovery. The physical part is just a metaphor for an internal transformation.
Some quotes:
To travel is better than to arrive. (Pirsig, Zen and the Art of Motorcycle Maintenance)
It's the going, not the getting there, that's good. (Harry Chapin, Greyhound)
Nothing will ever bridge the gulf between the man who left, and the one who stayed behind. (?)
A razor and a change of shirt. He who would travel happily must travel light. (Saint-Exupéry, Wind, Sand, and Stars)