Yamato Nadeshiko Shichi Henge is about Nakahara Sunako, a girl called "ugly" by a boy, who happened to be the first and only person to whom she confessed her love. This incident sparks a life change, and as a result Sunako shuns all forms of beauty, both in herself as well as in life. Concerned by her change for the worst, Sunako's aunt, the owner of a beautiful mansion where four very handsome students live, offers the guys free rent in her mansion if they can turn Sunako into a 'perfect lady'.