The story of the movie will be the same as the
manga and anime, and takes place in Japan during the Sengoku Period (aka The Warring States period). The rest of the story is as follows:
ﾂ"Forty-eight major demons, known as majins (demon gods), sense the impending birth of a powerful human, who will grow up to be the vanquisher of demonkind.
The forty-eight majins make a deal with the samurai Kagemitsu Daigo–who is the father of the yet-unborn child–wherein Daigo pledges forty-eight body parts of his unborn son to the majins, receiving in return the majins' guarantee that Kagemitsu will be unbeatable in any warfare and become the lord protector of the entire Japan. Indeed, the boy is born without forty-eight body parts; Kagemitsu puts the neonate in a basket and floats him down a river.
Fortunately the infant is rescued by a physician named Jukai who, over the period of many years, devises many cunning prosthetics so that the boy ﾂ― named Hyakkimaru (translation: One Hundred Ogre Boy) by Jukai ﾂ― can function like a normal person. Also Hyakkimaru has many supernatural powers which allow him to see, talk, and hear, despite having no eyes, mouth, or ears.
Upon reaching adulthood, Hyakkimaru embarks on a journey to vanquish the forty-eight majins and reclaim his body parts; he is soon joined by Dororo, a precocious female street urchin and self-styled ﾂ"greatest thief in all of Japan.ﾂ" Together, Hyakkimaru and Dororo travels the feudal Japan, helping the oppressed people and defeating the demons, in the hope that one day Hyakkimaru will win back all his body parts from the forty-eight majins.ﾂ"