I don't think there is any way to tell from "san" used with a family name. Perhaps a step forward if adopted in place of "kun" at work settings, for instance, insofar as it could cut down on sex discrimination or harassment.
whether man or woman, "san" applies to someone who is the superior or senior than you, famous people and otherwise has the position entertained as a client or guest at present.
e.g. Prime Minister Koizumi is called Koizumi-san.
such upper ranked people usually attach male junior people or follwers "kun". but to female people, they attach "san".