The Tokyo Metropolitan Institute of Medical Science (公益財団法人 東京都医学総合研究所) began operations in April 2011 as a brand new institute by the merger of three Tokyo metropolitan government-operated institutes, namely, Tokyo Metropolitan Institute for Neuroscience, Tokyo Institute of Psychiatry, and the Tokyo Metropolitan Institute of Medical Science. The ultimate goal of the institute is to improve the health and welfare of the citizens of the Tokyo city as well as those of our country through original discovery on the pathology and molecular basis of diseases and through the development of novel strategies for prediction, prevention, diagnosis and therapy of various diseases including mental disorders.